Electric Literature of 51738-07-9, The chemical industry reduces the impact on the environment during synthesis 51738-07-9, name is 2-Chloro-6-iodobenzaldehyde, I believe this compound will play a more active role in future production and life.
The mixture of TsNHNH2 (3.16 mmol, 1.0 eq) and DME (6.0 mL) was stirred and heated to 60 Cuntil a clear solution was obtained. The mixture was cooled to 25 C, and then 2-chloro-6-iodobenzaldehyde (3.2 mmol, 1 eq) dissolved in DME (2 mL) was added dropwise to the mixtureunder stirring. After approximately 1 h, CuI (0.32 mmol, 10 mol %), diethyl H-phosphonate (2.88mmol, 1.0 eq) and Cs2CO3 (4.74 mmol, 1.5 eq) were added sequentially to the reaction mixture at25 C. The mixture was then heated under stirring at 80 C for 3 h. When the reaction wascomplete (TLC control), the mixture was allowed to cool to 25 C. It was then filtered through ashort plug of SiO2 (AcOEt). The solvent was evaporated in vacuum. The residue was purified bysilica gel column chromatography (40 % EtOAc/petroleum ether) to afford an oil, 0.40 g, (35%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-6-iodobenzaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Roehrig, Ute F.; Majjigapu, Somi Reddy; Caldelari, Daniela; Dilek, Nahzli; Reichenbach, Patrick; Ascencao, Kelly; Irving, Melita; Coukos, George; Vogel, Pierre; Zoete, Vincent; Michielin, Olivier; Bioorganic and Medicinal Chemistry Letters; vol. 26; 17; (2016); p. 4330 – 4333;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com