13194-68-8, A common heterocyclic compound, 13194-68-8, name is 4-Iodo-2-methylaniline, molecular formula is C7H8IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a mixture of costunolide (0.04 mmol), triethylamine (0.12 mmol) and substituted aryl iodide (0.045 mmol) in DMF (200 muL) were added Palladium (II) acetate (0.002 mmol) at room temperature under inert atmosphere. The reaction mixture was then heated at 80-90 C for 14-16 h. The progress of the reaction was monitored by TLC; it indicated consumption of reactants. The reaction mixture was brought to room temperature and diluted with water (2 mL) and resultant mixture was extracted with Et2O (2 mL x 5). The combined organic layers were evaporated under reduced pressure and dried over Na2SO4 to get the crude mixture, which was purified by column chromatography using (100-200 silica gel mesh) to yield pure compounds.
The synthetic route of 4-Iodo-2-methylaniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Vadaparthi, P. R. Rao; Pavan Kumar; Kumar; Venkanna; Lakshma Nayak; Ramakrishna; Babu, K. Suresh; Medicinal Chemistry Research; vol. 24; 7; (2015); p. 2871 – 2878;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com