5469-33-0, name is (Iodomethyl)cyclohexane, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of (Iodomethyl)cyclohexane
[0344] To a solution of ethyl 8-CHLORO-6-HYDROXY-2- (TRIFLUOROMETHYL)-2H-CHROMENE-3- carboxylate prepared as in Example 17a, Step 3 (1.00 g, 3.10 mmole) in anhydrous DMF (10.0 mL) was added KI (51.5 mg, (0.310 mmole), K2CO3 (1.29 g, 9.30 mmole) and cyclohexyl iodide (1.20 mL, 9.30 mmole). The suspension was heated at 50 C for 17 h and then the temperature was slowly raised to 80 C and stirred overnight. Additional cyclohexyl iodide (1.20 mL, 9.30 mmole) was added and the temperature was maintained at 100-120 C for 3 days. The mixture was then cooled and poured into H20 (200 mL), which was saturated with solid NaCl. Following extraction with EtOAc (2 X 100 mL), the combined extracts were washed with brine (3 X 100 mL) and concentrated in vacuo. Purification by silica chromatography (6: 1 hexanes: EtOAc) gave 45 mg (3.5% yield) of the product: EIHRMS M/Z 404.0999 (M+, CL9H2OCIF304, Calc’d 404.1002).
The synthetic route of 5469-33-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACIA CORPORATION; WO2004/87686; (2004); A2;; ; Patent; PHARMACIA CORPORATION; WO2004/87687; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com