Related Products of 19393-94-3,Some common heterocyclic compound, 19393-94-3, name is 2,4-Dibromo-1-iodobenzene, molecular formula is C6H3Br2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 30.0 g of intermediate 1-1,500 ml of N,N-dimethylformamide to a 1 L three-necked flask, and replace the nitrogen gas. Then added 75.3 g of intermediate 1-2, 57.5 g of potassium carbonate, 1.2 g of bis(2-diphenylphosphinophenyl) ether, 2.4 g of palladium acetate; The reaction solution was heated to 150 C, and the reaction was stirred for 24 hours. The reaction was stopped after TLC was monitored to complete the reaction. After the reaction solution was cooled to room temperature, it was poured into 1.5 L of water to precipitate a solid. After washing with water to neutral, the crude product was passed through a column, and toluene was recrystallized to give 42.4 g of intermediate 1 in a yield of 68.5%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,4-Dibromo-1-iodobenzene, its application will become more common.