Application of 689260-53-5,Some common heterocyclic compound, 689260-53-5, name is 2-Bromo-5-iodo-1,3-dimethylbenzene, molecular formula is C8H8BrI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 2,5-dibromo-1 ,3-dimethylbenzene (2.00 g), 1 -furan-3-ylboronic acid (856 mg), and 2 M aqueous Na2CO3 solution (1 1 ml_) in 1 ,4-dioxane (40 ml_) is purged with argon for 5 min. Tetrakis-triphenylphosphine-palladium-(O) (270 mg) is added and the mixture is stirred at 100 C over n ight. More tetrakis- triphenylphosphine-palladium-(O) (50 mg) is added and the mixture is stirred for another 5 h at 100 C. After cooling to room temperature the mixture is diluted with ethyl acetate and aqueous NH CI solution. The aqueous phase is extracted with ethyl acetate and the combined extracts are washed with brine, dried over MgSO4 and concentrated in vacuo. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate 100:0?90:10) to give the title compound. LC (method 7): tR = 1 .22 min; Mass spectrum (Epsilon ): m/z = 250 [M]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-5-iodo-1,3-dimethylbenzene, its application will become more common.