Adding a certain compound to certain chemical reactions, such as: 4387-36-4, name is 2-Iodobenzonitrile, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4387-36-4, name: 2-Iodobenzonitrile
This compound was prepared by following aliterature procedure.2 A solution of o-iodobenzonitrile(0.916 g, 4 mmol) in THF (0.5 mL)was added drop-wise to 1 M LiN(SiMe3)2 in anhydrous THF (4.4 mL, 4.4mmol) at room temperature and the reaction mixture was stirred at sametemperature overnight. i-PrOH (3 mL) was added and thecrude reaction mixture was bubbled with HCl (gas) for 15 min. The mixture waskept at 0 °C overnight. The precipitated product was filtered and washed withdiethyl ether to yield titled product as a white solid (0.961 g, 85percent). Mp291°C; 1H NMR (500 MHz, DMSO-d6) delta 8.90 (s, 4H), 8.01 (dd, J = 8.0, 1.0 Hz, 1H), 7.63 ? 7.49 (m,2H), 7.35 (ddd, J = 7.9, 7.2, 2.0 Hz,1H); 13C NMR (126 MHz, DMSO) delta 167.64, 139.23, 135.90, 132.71,128.92, 128.27, 94.88; IR (neat) 3038, 1664, 1588, 1404 cm-1; HRMScalcd for C7H8IN2 (M++1) + [-HCl]:246.9727, found 246.9719.
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