In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 71838-16-9 as follows. Recommanded Product: 2-Bromo-1-iodo-4-methylbenzene
Step A. 4-(2′-bromo-4′-methylbiphenyl-4-yl)-1-(2,2,2-trifluoroethyl)piperidine A mixture of 2-bromo-1-iodo-4-methylbenzene (0.764 g, 2.57 mmol), the title compound from Example 60 Step B (1.00 g, 2.71 mmol), dichloro bis(triphenylphosphine)palladium(II) (0.095 g, 0.135 mmol), sodium carbonate (5.42 mL of 1 M solution, 5.42 mmol) and MeCN (5.42 mL) was heated at 110 C. overnight. Organic layer was separated. Aqueous layer was extracted with hexanes-EtOAc. The organic layers were combined and concentrated. Silica gel flash chromatography eluting with hexanes:EtOAc (20:1 to 9:1 v/v) gave the title compound: LCMS m/z 414.0 [M+H+]; 1H NMR (500 MHz, CDCl3) delta 7.54 (s, 1H), 7.40 (d, J=8.1 Hz, 2H), 7.31 (d, J=8.1 Hz, 2H), 7.26 (d, J=7.8 Hz, 1H), 7.20 (d, J=7.8 Hz, 1H), 3.16 (m, 2H), 3.08 (q, J=9.8 Hz, 2H), 2.57 (m, 3H), 2.42 (s, 3H). 1.95-1.88 (m, 4H).
According to the analysis of related databases, 71838-16-9, the application of this compound in the production field has become more and more popular.