Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6828-35-9, name is 5-Chloro-2-iodoaniline, A new synthetic method of this compound is introduced below., COA of Formula: C6H5ClIN
General procedure: Using a dried tube, equipped with a magnetic stirrer and a septum, 2-iodoaniline (0.22 g,1.0mmol) was dissolved in DMSO (3mL), and KOt-Bu (0.34 g, 3mmol) was added. Themixture was stirred for 5min, then dithiocarbamate (0.296 g, 1.5mmol) was added. Thereaction mixture was heated at 100C and checked by TLC until the starting material wasfinished. The reaction mixture was cooled down to room temperature and then quenchedwith sat. NH4Cl solution (5mL) and extracted with ethyl acetate (10mL×3), dried overanhydrous Na2SO4 and concentrated under vacuum. The residue was purified by flashcolumn chromatography to afford the desired product (146mg, 82%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.