Electric Literature of 460-37-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A solution of 880 mg (2.76 mmol) of the compound from Ex. 114A in 12 mL of DMF was treated with 1:35 g (4.15 mmol) cesium carbonate and stirred for 20 min at RT.Then 929 mg (4.15 mmol) 3,3,3-trifluoro-1-iodopropane were added, and the mixture was 2 h at 80 C heats.After cooling to RT was diluted with about 100 ml of ethyl acetate and washed twice with about 100 ml of water and once with 100 ml of saturated sodium chloride solution.After drying over anhydrous magnesium sulfate, was filtered and concentrated.The crude product was purified by preparative HPLC (method 6).The product fractions were combined and concentrated and the residue dried under high vacuum.There were 750 mg (63% d. Th.) Of the title compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,1-Trifluoro-3-iodopropane, other downstream synthetic routes, hurry up and to see.