Electric Literature of 886762-73-8, The chemical industry reduces the impact on the environment during synthesis 886762-73-8, name is 2-Fluoro-6-iodoaniline, I believe this compound will play a more active role in future production and life.
3.90.2. Step ii): 2-ethyl-6-fluoroaniline PdCl2dppf (0.1 eq, 375 mg), Cs2C03 (3 eq, 4.5 g) and 6-fluoro-2-iodoaniline (1 eq, 1.1 g) are dissolved in dry DMF (50 mL) in a 250 mL round bottom flask. The suspension is degassed under nitrogen atmosphere for 10 min, followed by the addition of triethylborane (1M in hexane, 1.3 eq, 6.0 mL). The reaction is heated to 55C for 2 h, using a condenser. Upon completion of the reaction, as shown by LC-MS, the suspension is filtered over a Celite pad, which is washed with DCM. The filtrate is poured into water and extraction with DCM (3 x 50 mL) is performed. The combined organic layers are dried (Na2S04) and concentrated in vacuo. The residue is purified by silica chromatography (petroleum ether/EtOAc; 100:0 to 80:20) to give the desired product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-6-iodoaniline, other downstream synthetic routes, hurry up and to see.