Reference of 3032-81-3, These common heterocyclic compound, 3032-81-3, name is 1,3-Dichloro-5-iodobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1 (10mg, 0.057mmol), 2 (31mg, 0.114mmol) and CS2CO3 (95mg, 0.29mmol) in DMF (lmL) were added 2 mg of Pd(dba)2 and 2 mg of Xantphos. The suspension was degassed under vacuum and purged with N2 several times. The mixture was stirred at 120 °C for lh. LCMS showed the SM was consumed completely. Then the reaction mixture was diluted with EA (5mL) and washed with brine (2mL) twice. The organic solution was dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure and purified by p-TLC to give the desired compound Compound 120 (6mg, yield: 33.3percent). LCMS: m/z, 321.0 (M+H)+; 1HNMR:(d-CDCl3, 400MHz): delta 8.65(s, 1H), 7.67(t, J=7.2, 1H), 7.45(d, J=7.6, 1H), 7.27(t, J=6.0, 1H), 6.70(s, 1H), 6.23(d, J=1.2, 2H), 4.14~4.30(m, 4H).
The synthetic route of 3032-81-3 has been constantly updated, and we look forward to future research findings.