In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5876-51-7, name is 5-Iodobenzo[d][1,3]dioxole belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H5IO2
General procedure: 2-Phenylindole (408 mg, 2.0 mmol, 1 equiv), aryl iodide (2.0 mmol, 1 equiv), NaOt-Bu (288mg, 3.0 mmol,, 1.5 equiv), CNT-CuO (contained Cu 9.1 %, 70 mg, 5.0 mol%), were reacted in DMSO (10.0 mL) at 120 C for 12 h. The mixture charged to separating funnel added water, extracted with EtOAc. The organic layer washed with water many times for removing water, dried over magnesium sulfate. Evaporation of the solvent under reduced pressure provided the crude product, which was purified by column chromatography on silica gel.(eluent : hexane / ethyl acetate = 10 / 1).
The synthetic route of 5876-51-7 has been constantly updated, and we look forward to future research findings.