Electric Literature of 202982-67-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In a Schlenk tube, a solution of 4-Chloro-3-fluoroiodobenzene (7.3 g, 28.4 mmol), K3PO4 (16.1 g, 75.9 mmol), (S)-methylpyrrolidine-3-carboxylate (1271) hydrochloride (3.1 g, 19.0 mmol) and P(tBu)3 HBF4 (551 mg, 1.90 mmol) in dioxane (150 mL) was purged with N2 (3x). Pd(OAc)2 (213 mg; 0.95 mmol) was added and the reaction mixture was stirred at 100C for 16 h, then cooled down to rt. The mixture was diluted with EtOAc and water. The layers were separated. The aqueous layer was extrated with EtOAc (twice). The combined organic layers were washed with brine, dried over MgS04, filtered and the solvent was removed under reduced pressure. The residue was purified by preparative LC (irregular SiOH, 15-40 muiotaeta, 220 g Grace, liquid injection (Heptane), mobile phase gradient: from Heptane 100%, to heptane 70%>, EtOAc 30%>) to give 1.91 g (37%) of intermediate (U6) as an orange oil.
The synthetic route of 4-Chloro-3-fluoroiodobenzene has been constantly updated, and we look forward to future research findings.