Electric Literature of 460-37-7, These common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 91Preparation of Compound 496Step A – synthesis of compound 9JBCompound 91 A (5.Og, 22mol) was added to Mg turnings (0.7Og, 29mga) and catalytic iodine in ether (3OmL). After Ih, the reaction was cooled to 0 0C and treated with benzaldehyde (2.08g, 20mmol). After Ih , satd. NH4Cl was added (10OmL). The ether was concentrated to leave a yellow oil, taken up in CH2Cl2 (4OmL), and treated with PCC (12.0g, 56mmol) for 4h. Hexane (30ml) was added, the solid filtered and concentrated to give crude compound 91B as a yellow solid.
Statistics shows that 1,1,1-Trifluoro-3-iodopropane is playing an increasingly important role. we look forward to future research findings about 460-37-7.