Electric Literature of 16932-44-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16932-44-8, name is 2-Iodo-1,3-dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 2,6-dimethoxyiodobenzene (40.1 mg, 151 mumol), Bu3SnH (48.7 muL, 181 mumol), and V-65 (7.5 mg, 30.2 mumol) in THF-d8 (4 mL) was stirred at reflux for 3 h. Bu3SnH (48.7 muL, 181 mumol) and V-65 (7.5 mg, 30.2 mumol) were added, and the mixture was stirred at reflux for 2 h. The mixture was concentrated in vacuo, and the residue was purified by column chromatography on silica gel (pentane/Et2O=40:1) to give 2-deutero-1,3-dimethoxybenzene (21.1 mg, 100%). 1H NMR (400 MHz): 3.72 (s, 6H, O-CH3), 6.46-6.51 (m, 2.15H, 2-H, 4-H, 6-H), 7.17 (t, J=8.1 Hz, 1H, 5-H); 2H NMR: 6.50 (br); MS(EI+): m/z 139 [M]+; HRMS (EI+): calcd for C8H92HO2 [M]+: 139.07436, found: 139.07515.
The chemical industry reduces the impact on the environment during synthesis 2-Iodo-1,3-dimethoxybenzene. I believe this compound will play a more active role in future production and life.