Introduction of a new synthetic route about 2-(4-Iodophenyl)acetonitrile

According to the analysis of related databases, 51628-12-7, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 51628-12-7, name is 2-(4-Iodophenyl)acetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H6IN

1L pressure kettle,121.5 g (0.5 mol) of p-iodophenylacetonitrile,800 g (2 mol) of 10% sodium hydroxide,10.9 g (0.075 mol) of 8-hydroxyquinoline,12.8g (0.075mol) after adding copper chloride, the kettle heated to 50 ~ 55 , to maintain The pressure of the reactor is 0MPaG, the temperature of the reaction system is kept between 50 and 55 DEG C, and the reaction is carried out for 7 hours. The reaction solution is finished and the reaction vessel is cooled. The pH of the reaction solution is adjusted to between 7 and 8 with 36% hydrochloric acid. The mother liquor was adjusted to pH with 30% NaOH13 ~ 14, get dark red transparent liquid, sodium p-hydroxyphenylacetate solution, weighing 755g, the detection of p-hydroxyphenylacetic acid content of 9.79%, the yield was 97.3%.

According to the analysis of related databases, 51628-12-7, the application of this compound in the production field has become more and more popular.