Electric Literature of 444-29-1, A common heterocyclic compound, 444-29-1, name is 1-Iodo-2-(trifluoromethyl)benzene, molecular formula is C7H4F3I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of aryl halides (0.5 mmol), aryl sulfinates (0.75 mmol), Pd(dppf)Cl2 (2.5 mol percent), P(OPh)3 (5 mol percent), K2CO3 (1.5 mmol) and 2 mL of DMF in a schlenk tube was heated to 150 °C under inert atmosphere (24 h for aryl iodides and 26 h for aryl bromides). The reaction mixture was cooled to room temperature, diluted with ethyl acetate and filtered through a plug of Celite. The filtrate was washed sequentially with H2O and brine. The organic layer was separated, dried (Na2SO4), and concentrated under vacuum. The crude product was purified by column chromatography (silica gel; petroleum ether). All the products were analyzed by GC-MS. 1H NMR, 13C NMR and IR of only representative products are given, as all the products are highly reported.
The synthetic route of 444-29-1 has been constantly updated, and we look forward to future research findings.