Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 391211-97-5, name is 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid
EXAMPLE 6 1-F3, 4-DIFLUORO-2- (2-FLUORO-4-VINVIPHENYLAMINO)-PHENVLL-2-HYDROXV-ETHANONE Step A: Synthesis of R3, 4-DIFLUORO-2- (2-FLUORO-4-IODOD-PHENYLAMINO)-PHENVLL- methanol. To 3, 4-DIFLUORO-2-(2-FLUORO-4-IODO-PHENYLAMINO)-BENZOIC acid (10. 0g, 25. 4MMOL) in tetrahydrofuran was added, borane in tetrahydrofuran (38.2mL of a 1. OM solution) after 16 hours stirring at room temperature, the reaction was complete and quenched by careful addition of 2% HCI (100ML). The mixture was stirred for 1 H, brine was added and the organic layer was separated which was dried and evaporated to give a colorless solid (7. 13g 74%) that was recrystalized from hot dichloromethane/hexane to give an analytical sample. MS (APCI+) 380 (M+1+) ; H NMR (400mHz, DMSO) 7.62 (s, 1H), 7.50 (d, 1H), 7.24 (m, 3H), 6.29 (d of t, 1 H), 5.35 (t, 1 H), 4.42 (d, 1 H).
According to the analysis of related databases, 391211-97-5, the application of this compound in the production field has become more and more popular.