Related Products of 627-32-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627-32-7, name is 3-Iodo-1-propanol belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 1 -(4-hydroxyphenyl)-3 -methyl-i H-pyrazole-4-carbaldehyde (214 mg, 1.057 mmol, 1 eq.), 3-iodopropan-i-ol (1.27 g, 1.268 mmol, 1.2 eq), K2C03 (292 mg, 2.114 mmol, 2 eq.) in 5 mL CH3CN was heated at reflux for 24 h. The mixture was thenfiltered, and the remaining solid was washed with EtOAc twice (10 mL each time). The organic layers were concentrated and purified using silica column chromatography to afford 1 -(4-(3 -hydroxypropoxy)phenyl)-3 -methyl-i H-pyrazole-4-carbaldehyde as a yellow solid (190 mg, yield: 69%). ?H NIVIR (CDC13) oe (ppm) 2.04-2.12 (m, 2H), 2.55 (s, 3H), 3.86-3.90 (t, 2H), 4.15-4.19 (t, 2H), 7.03 (d, J= 9.0 Hz, 2H), 7.34 (d, J= 9.0 Hz,2H), 8.03 (s, 1H), 9.96 (s, 1H); ?3C NIVIR (CDC13) oe (ppm) 11.55, 31.88, 59.94, 65.77,114.97, 121.48, 126.74, 131.18, 142.13, 143.41, 159.13, 184.94;ESI-MS(M+H)m/z=261.0.
The synthetic route of 3-Iodo-1-propanol has been constantly updated, and we look forward to future research findings.