Adding a certain compound to certain chemical reactions, such as: 696-41-3, name is 3-Iodobenzaldehyde, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 696-41-3, SDS of cas: 696-41-3
General procedure: Benzaldehyde (1.0 mmol), TMTD (1.1 mmol), CuI (10 mol%), and DTBP (4.0 equiv) were added to a dried sealed tube equipped with a septum and magnetic stirrer bar, EtOAc (2 mL) was then added. (Caution. The sealed tube is a pressure-proof tube with a septum.) The mixture was stirred at 120 C and checked by thin-layer chromatography (TLC) until the starting material was consumed (ca. 7-8 h). The reaction was cooled to r.t., quenched with sat. NH4Cl solution (5 mL), and then extracted with EtOAc (3 × 10 mL). The crude solution was dried over anhydrous Na2SO4 and evaporated under vacuum. The residue was purified by flash column chromatography to afford the desired product.
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