Electric Literature of 98-61-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98-61-3, name is 4-Iodobenzenesulfonyl chloride belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
5.1.16 4-((4-Iodophenylsulfonamido)methyl)-N-(pyridin-3-yl)benzamide (28) A mixture of amine 27 (727 mg, 3.2 mmol) and 4-iodobenzenesulfonyl chloride (970 mg, 3.2 mmol) in dry pyridine (10 mL) was stirred at 20 C for 16 h. The solvent was evaporated and the residue stirred in water (20 mL) for 1 h. The precipitate was filtered, washed with water (5 mL) and dried. The crude solid was purified by column chromatography, eluting with a gradient (0-20%) of MeOH/EtOAc, to give benzamide 28 (1.47 g, 93%) as a cream powder: mp (MeOH/EtOAc) 249-251 C; 1H NMR delta 10.36 (s, 1H, NHCO), 8.93 (d, J = 2.3 Hz, 1H, H-2′), 8.34 (br s, 1H, NHSO2), 8.31 (dd, J = 4.7, 1.5 Hz, 1H, H-6′), 8.18 (ddd, J = 8.3, 2.5, 1.5 Hz, 1H, H-4′), 7.97 (ddd, J = 8.6, 2.2, 1.9 Hz, 2H, H-2″, H-6″), 7.90 (br d, J = 8.3 Hz, 2H, H-2, H-6), 7.56 (ddd, J = 8.6, 2.2, 1.9 Hz, 2H, H-3″, H-5″), 7.37-7.42 (m, 3H, H-3, H-5, H-5′), 4.09 (s, 2H, CH2N); 13C NMR delta 165.5, 144.5, 142.0, 141.6, 140.3, 138.1 (2), 135.8, 133.1, 128.2 (2), 127.7 (2), 127.5 (2), 127.3, 123.5, 100.3, 45.7; MS m/z 494.6 (MH+, 100%). Anal. Calcd for C19H16IN3O3S: C, 46.26; H, 3.27; N, 8.52. Found: C, 46.43; H, 3.30; N, 8.52.
The synthetic route of 4-Iodobenzenesulfonyl chloride has been constantly updated, and we look forward to future research findings.