In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6940-76-7, name is 1-Chloro-3-iodopropane belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 1-Chloro-3-iodopropane
3,4-Dihydroquinolin-2(1 H)-one (2.0 g, 13.6 mmol) dissolved in acetonitrile (10 mL) at 25 C, Cs2C03 (13.0 g, 40.8 mmol) was added and the reaction was stirred at 60C for 1 h then cooled to at 25 C. 1-Chloro-3-iodopropane (3.61 g, 17.7 mmol) was then added and the resulting reaction mixture was stirred at 80C for 48 h. After this time, the reaction mixture was partitioned between cold H20 (150 mL) and EtOAc (100 mL), the aqueous layer was further extracted with EtOAc (2 x 100 mL), the organic layers were combined, dried (Na2S0 ), solvents were removed in vacuo and the residue was purified by column chromatography (Normal silica, mesh size: 60-120, 20.0 % to 25.0 % EtOAc in Hexane) to give 1 -(3-chloropropyl)-3,4- dihydroquinolin-2(1 H)-one (1 .48 g, 48.84 %) as yellow gum. The data for the title compound is in Table 2.
The synthetic route of 6940-76-7 has been constantly updated, and we look forward to future research findings.