The chemical industry reduces the impact on the environment during synthesis 6293-83-0, name is 2-Iodo-4-nitroaniline, I believe this compound will play a more active role in future production and life. 6293-83-0
In a nitrogen-purged four-necked flask, 2-iodo-4-nitroaniline(5.11 g, 19.4 mmol), Bis(triphenylphosphine)palladium(II) dichloride (281.7 mg, 0.401 mmol), Copper iodide (160.7 mg, 0.844 mmol),And 30 ml of diethylamine, and the mixture was stirred at room temperature (20 C.) for 10 minutes.Thereafter, N-Boc-propargylamine (3.72 g, 24.0 mmol) was added and the mixture was stirred at room temperature (20 C.) for 4 hours. After disappearance of the raw material was confirmed by HPLC (high performance liquid chromatography), 200 ml of ethyl acetate and 200 ml of 1 M ammonium chloride aqueous solution were added and extracted. The obtained organic layer was washed twice with 1 M ammonium chloride aqueous solution and dried over anhydrous magnesium sulfate. After removing the drying agent, the filtrate was concentrated and purified by silica gel column chromatography (distillate: ethyl acetate: hexane = 3: 7 (volume ratio)). The yield was 4.97 g, and the yield was 88.0%.
The chemical industry reduces the impact on the environment during synthesis 6293-83-0. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NISSAN CHEMICAL INDUSTRIES LIMITED; SAKUMOTO, NAOKI; (63 pag.)JP5846230; (2016); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com