Synthetic Route of 619-58-9, The chemical industry reduces the impact on the environment during synthesis 619-58-9, name is 4-Iodobenzoic acid, I believe this compound will play a more active role in future production and life.
A flame dried, 300-ml three-necked, round-bottomed flask equipped with a magnetic stirring bar was charged with 4-iodobenzoic acid 9 (10.0 g, 40.3 mmol) and THF (20.0 mL). To the solution were slowly added BH3·THF (1.06 M solution in THF, 60.0 mL, 63.6 mmol) at -20 C. After stirring for 12 h at 50 C, an additional portion of BH3·THF (1.06 M solution in THF, 60.0 mL, 63.6 mmol) was added at -20 C and the reaction mixture was refluxed for 2 h. The reaction was quenched with ice-H2O (100 mL) and K2CO3. The reaction mixture was concentrated under reduced pressure and the residue was extracted with EtOAc. The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified on a short pad of silica gel (Hexanes/EtOAc, 10:1) to give the titled alcohol S-1 (9.90 g, quant) as a white solid. Its spectral data were identical with those reported1 ; IR (KBr) 3500-3000, 1483, 1400, 1005, 791 cm-1; 1H NMR (500 MHz, CDCl3) d 7.66 (2H, d, J = 8.0 Hz), 7.07 (2H, d, J = 8.0 Hz), 4.59 (2H, s), 2.11 (1H, s); 13C NMR (125 MHz, CDCl3) d 140.4, 137.5, 128.7, 92.9, 64.5.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodobenzoic acid, other downstream synthetic routes, hurry up and to see.