Synthetic Route of 6828-35-9, The chemical industry reduces the impact on the environment during synthesis 6828-35-9, name is 5-Chloro-2-iodoaniline, I believe this compound will play a more active role in future production and life.
3-phenyl-2,2-dihydroxy-3-oxopropionic acid ethyl ester (0.05 mmol) was added to the reaction flask.2-iodo-5-chloroaniline (0.05 mmol),1,3-cyclohexanedione (0.05mmol),(R)-3,3,3′,3′-tetramethylspirophosphoric acid (0.005 mmol) represented by the formula (V),Anhydrous Na2SO4 (200mg),Inject 1 mL of dichloromethane and react at 65 C for 16 hours.After completion of the reaction, the residue was directly applied to silica gel column chromatography eluting with ethyl acetate / petroleum ether = 1:30 to give the corresponding optically active 1-arylindole derivative (I-4), yield 73% ;
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloro-2-iodoaniline, other downstream synthetic routes, hurry up and to see.