Reference of 620-05-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 620-05-3, name is (Iodomethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: In a flame-dried round-bottom flask, beta-amidoester (9) (1 mmol; 1 equiv) was taken in DMF (5 mL) at room temperature. To this reaction mixture KOt-Bu (1.2 mmol; 1.2 equiv) was added. After 5 minutes of stirring at same temperature alkyl halide (1.05 mmol; 1.05 equiv) was added and stirring was continued for 15 minutes. Upon completion of the alkylation (judged by TLC), it was diluted with 10 mL of EtOAc and quenched with water. The organic extracts were dried over anhydrous sodium sulphate and concentrated under vacuum. The crude product was purified by flash chromatography (hexane and EtOAc as eluents) to afford compounds 10.
The synthetic route of (Iodomethyl)benzene has been constantly updated, and we look forward to future research findings.