64248-58-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 64248-58-4 name is 1,2-Difluoro-4-iodobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3,4-difluoro-iodobenzene (100mg, 0.41mmoL) and piperazine (32mg, 0.41mmoL) were mixed in 5mL of dioxane, under a nitrogen atmosphere, followed by triethylamine (54mg, 0.45mmoL), 2.5 mg of X-phos (2- dicyclohexyl-P-2 ‘, 4′, 6’-triisopropyl biphenyl) and 2.5mg of Pd2 (dba) 3 (tris (dibenzylideneacetone) dipalladium) , then stirred at room temperature for 3 hours. Then vacuum to spin dioxane was added 20mL of water and 20mL of ethyl acetate, the organic phase was dried over sodium sulfate, spin dry and separate living give 37mg of product. The above product (37mg, 0.19mmoL) and piperazine (40mg, 0.55mmol), potassium carbonate (60mg, 0.43 mmol) were mixed in N, N- dimethylacetamide in a microwave at 150 stirred for 2 hours, and then spin to N, N- dimethylacetamide, purified by column to give (3-fluoro-4- (piperazin-1-yl) phenyl) dimethyl phosphine oxide (40mg).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Difluoro-4-iodobenzene, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Hansoh BioMedical Co., Ltd.; Jiangsu Hansoh Pharmaceutical Group Co., Ltd.; Yang, Fei; Zhang, Xiuchun; Sun, Xingyi; Wei, Mingsong; Wang, Chunjuan; Tong, Chaolong; Li, Chenghai; Bao, Rudi; Yu, Hongping; Xu, Yaochang; (52 pag.)CN105712928; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com