Reference of 98-61-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98-61-3, name is 4-Iodobenzenesulfonyl chloride belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
7-PIPSYL-GC (6).; To a suspension of GC (3,99. 8 mg, 0.227 mmol) and 4-iodobenzenesulfonyl chloride (205.7 mg, 0.680 mmol, 3 equiv) in CH2CL2 (2.25 mL) was added pyridine (73 mL, 0.906 mmol, 4 equiv) and the reaction mixture was stirred for 26 h. The solvent was removed under reduced pressure, the residue dissolved in EtOAc and washed with 1M aq. HC1, brine and dried with MGSO4. The crude product was purified by flash column chromatography (gradient 40-99 % EtOAc/hexanes, 1 % AcOH) to obtain 113.8 mg of pure 6 (73% yield) and 24.3 mg of recovered GC (25 %). 1H-NMR (400 MHz, DMSO-d6) 8 8.18-8. 10 (m, 2HA), 7.78-7. 70 (m, 2H), 7.57 (d, J = 5. 5 Hz, 1H, 10- H), 6.52 (s, 1H, 3-OH), 6.13 (s, 1H, 12-H), 5.30 (d, J = 4.2 Hz, 1H, 1-OH), 5.16 (D, J = 4.1 Hz, 1H, 6-H), 5.01 (d, J = 5.5 Hz, 1H, 10-H), 4.85 (dd, J = 12.4, 4.1 Hz, 1H, 7-H), 4. 60 (d, J = 6.5 Hz, 1H, 2-H), 4.09 (dd, J = 6.5, 4.2 Hz, 1H, 1-H), 2.80 (q, J = 7.1 Hz, 1H, 14-H), 1.95 (d, J = 12.4 Hz, 1H, 8- H), 1.10 (d, J = 7.1 Hz, 3H, 16-CH3), 0.98 (s, 9H, tBu) ; 13C- NMR (75 MHz, MEOD) 5 8.16, 29.24, 33.20, 43.17, 50.03, 64.78, 68.71, 70.24, 75.03, 76.67, 81.10, 84.50, 93.47, 100.06, 103.62, 111.14, 130.49, 137.04, 140.39, 171.66, 174.40, 178.05. HRMS (FAB) calcd for C26H28013SI 707.0295, found 707.0265.
The synthetic route of 4-Iodobenzenesulfonyl chloride has been constantly updated, and we look forward to future research findings.