Related Products of 260558-15-4, The chemical industry reduces the impact on the environment during synthesis 260558-15-4, name is 4-Bromo-2-iodo-1-methylbenzene, I believe this compound will play a more active role in future production and life.
To a solution of 2-methyl-5-bromo-iodobenzene (12 g, 40.4 mmol) in tetrahydrofuran (75 ml), cooled to -78 C., was added a solution of isopropylmagnesium chloride (4.6 g, 44.5 mmol) in tetrahydrofuran (22.2 ml) dropwise over 20 minutes. After stirring at -78 C. for 30 minutes, the mixture was warmed slowly to -20 C. and stirred for 1 hour. After cooling again to -78 C., trimethylborate (8.4 g, 80.8 mmol) was added dropwise. After warming to 0 C., the mixture was stirred for 2 hours, treated with 1 M hydrochloric acid (35 ml), and extracted with ethyl acetate (2*50 ml). The combined extracts were washed with water (50 ml), dried over sodium sulfate, and concentrated under reduced pressure. The residual solid was suspended in hexane (50 ml), filtered, washed with hexane (30 ml) and dried under reduced pressure to provide 2-methyl-5-bromo-phenylboronic acid (7.32 g, 84% yield) as a white solid. 1H NMR (DMSO-d6) delta 7.92 (s, 1H), 7.46 (d, J=8.1 Hz, 1H), 7.13 (d, J=8.1 Hz, 1H), 2.59 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-iodo-1-methylbenzene, other downstream synthetic routes, hurry up and to see.