Continuously updated synthesis method about 1-Iodo-3-(trifluoromethyl)benzene

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 401-81-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Iodo-3-(trifluoromethyl)benzene

General procedure: In an oven-dried Schlenk tube iodoarenes 1 (0.25 mmol), arylboroicacids 2 (0.5 mmol), PdO/GO nano catalyst (5 mol%),K2CO3 (0.5 mmol) and solvent (DMSO) (1.0 mL) wereadded. The resulting reaction mixture was stirred at 120 Cfor 5-30 min. The progress of the reaction was monitoredby TLC. After completion of reaction, the reaction mixturewas allowed to cool to room temperature, then diluted with(approximately 10 mL) ethyl acetate and NH4Cl solution(approximately 10mL)was added followed by extractionwithethyl acetate. The organic layers were dried with Na2SO4 andconcentrated in reduced vacuum. Purification of the residue bysilica gel column chromatography using distilled petroleumether/ethyl acetate as the eluent furnished the biphenyls.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 401-81-0.

Reference:
Article; Lakshminarayana, Bhairi; Mahendar, Lodi; Chakraborty, Jhonti; Satyanarayana, Gedu; Subrahmanyam, Ch; Journal of Chemical Sciences; vol. 130; 5; (2018);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com