These common heterocyclic compound, 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C3H6I2
Nitrogen-extractedIn a 250 ml three-necked bottle, 2.33 g (1H-indol-2-yl)-1H-benzo[d]imidazole was weighed.(10 mmol), add 50 ml of dimethylformamide, stir well.Then add 2.8 g of potassium hydroxide (50 mmol) and stir at room temperature for 2-36 hours.As most of the potassium hydroxide dissolves, a thick, cloudy solution forms.Add 1.72 ml of 1,3-diiodopropane (15 mmol) and react at room temperature for 18-24 hours. Point board monitoring,When the reaction of raw materials is complete,The reaction was stopped and 40 ml of water and 30 ml of dichloromethane were added to the system.The mixture was further extracted with 30 ml of dichloromethane three times and the organic phases were combined and dried over anhydrous magnesium sulfate.After concentrating the organic phasePurification by column chromatography7,8-Dihydro-6H-benzo[4′,5′]imidazo[2′,1′:3,4][1,4]diaza [1,2-a]fluorene Body 1.23g, yield 45%, can be directly put into the next step reaction.
The synthetic route of 1,3-Diiodopropane(stabilized with Copper chip) has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hong Kong University Of Science And Technology Shenzhen Institute; Kuang Fuer; Li Dongsheng; Cai Peiying; (20 pag.)CN107459533; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com