Related Products of 42861-71-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 42861-71-2 as follows.
Step 1 : 3-(2- {4-[4-(2-Trifluoromethylbenzoyl)piperazino]phenyl-l-ethynyl)phenyl acetate: Prepared by coupling reaction of Intermediate 2 with 3-iodophenyl acetate to give the product as an off-white solid; IR (KBr) 2923, 2207, 1767, 1638, 1507, 1201, 1010, 775 cm”1; 1H NMR (300 MHz, DMSO-J6) delta 2.27 (s, 3H), 3.17-3.28 (m, 2H), 3.41-3.80 (m, 6H), 6.99 (d, J = 8.7 Hz, IH), 7.15 (d, J = 7.8 Hz, IH), 7.30 (s, IH), 7.38-7.47 (m, 2H), 7.55 (d, J= 7.5 Hz, IH), 7.68-7.80 (m, 3H), 7.85 (d, J = 7.8 Hz, IH), 8.32 (d, J = 1.8 Hz, IH); ESI-MS (m/z) 494.53 (M+H)+.
According to the analysis of related databases, 42861-71-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; WO2008/62276; (2008); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com