Electric Literature of 103962-05-6, These common heterocyclic compound, 103962-05-6, name is 1-Iodo-4-(trifluoromethoxy)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 220( .613g, 9.Olmmol), Cs2C03 (4.40g. 13.5 Immol), 224(2Og, 9.Olmmoi) andCu(OAc)2 (0. 16g) in 20mL DMF. The mixture was heated at 120¡ãC for the appropriate time andsubsequent cooling, the reaction mixture was diluted with saturated aqueous ammonium chloride.Products were isolated by extraction with EA. The organic layer was dried over anhydrousNa2SO4, filtered, and concentrated. Products 225 were purified by silica gel columnchromatography (1 40g, yield: 68percent).
The synthetic route of 103962-05-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com