In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 188815-32-9 as follows. COA of Formula: C7H4BrIO2
To a solution of 3-bromo-5-iodo-benzoic acid (commercially available from Avocado, 50g, 153 mmol, 1 equiv) in CH2CI2 (500 ml) was added 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (30.8 g, 160 mmol, 1.05 equiv), DMAP (14 g, 114 mmol, 0.75equiv) and fert-butanol (90 ml, 917 mmol, 6 equiv). The resulting mixture was stirred atroom temperature for 48 h. DMAP (4.67 g, 38 mmol, 0.25 equiv) was then added and thesolution was stirred for another 24 h then concentrated in vacua. The residue wasdissolved in AcOEt and washed sequentially with 2N aqueous HCI solution, 1N aqueousNaOH solution and brine, dried over MgSO4 and concentrated in vacua to give 1,1-dimethylethyl 3-bromo-5-iodobenzoate (D7) (50.6 g, 86%) as a brown solid which wasused in the next step without further purification.
According to the analysis of related databases, 188815-32-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/111022; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com