Related Products of 624-76-0, A common heterocyclic compound, 624-76-0, name is 2-Iodoethanol, molecular formula is C2H5IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Methoxy-2-methylthiopropionic acid S-(2-hydroxyethyr) ester (9); To 2.5 g (19 mmol) 8 in 20 ml of dry toluene at ice bath temperature under Ar was added 2.2 ml (14.6 mmol) DBU dropwise with stirring. Iodoethanol (1.2 ml, 14.6 mmol) in 5 ml dry toluene was added slowly to the rapidly stirred solution at O0C. The reaction mixture was then stirred for 18 hours at 5 0C. Reaction mixture was diluted with 200 ml of EtOAc and washed with 3 x 50 ml H2O. EtOAc layers were dried with Na2SO4, and solvent was removed in vacuo to give 4.7 g crude material. Silica gel chromatography with 20% EtOAc in hexanes provided 2.66 g, 79 % yield of (9). NMR 300 MHz, CDCl3, delta 3,75 (q, 2H, J=6 Hz), 3.33 (S, 3H), 3.06 (t, 2H, J=6 Hz), 2.02 (t, IH) and 1.39 (s, 6H) ppm.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; VALEANT RESEARCH & DEVELOPMENT; WO2006/122207; (2006); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com