Related Products of 1829-28-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1829-28-3, name is Ethyl 2-iodobenzoate belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
S-Phos (13mg, 0.03mmol, 10molpercent) was introduced in dry toluene (0.5mL) under Argon, then Pd(OAc)2 (4mg, 0.02mmol, 5molpercent) was added. The resulting solution was heated at 80¡ãC for 10min. A solution of N-(4-(tri(n-butyl)stannyl)pyridazin-3-yl)pivalamide 3b (150mg, 0.32mmol, 1.0equiv) in dry toluene (0.8mL) and ethyl 2-iodobenzoate (80muL, 0.48mmol, 1.5equiv) were successively added. The solution was refluxed overnight and the resulting mixture was evaporated to dryness. The crude product was purified by column chromatography (eluent: PE/EtOAc (6:4)) to give the desired product 5j (31mg, 49percent) as a yellow powder; mp>260¡ãC; IR (neat) nu (cm?1) 3156 (NH), 3047, 2918, 1654 (C=O), 1606, 1479, 1436, 1345, 1324; 1H NMR (300MHz, DMSO-d6) delta 12.55 (s, 1H), 9.17 (d, J=5.3Hz, 1H), 8.67 (d, J=7.9Hz, 1H), 8.60 (d, J=5.3Hz, 1H), 8.36 (d, J=7.9Hz, 1H), 7.97 (dd, J=7.9, 7.5Hz, 1H), 7.84 (dd, J=7.9, 7.5Hz, 1H); 13C NMR (75MHz, DMSO-d6) delta 161.3, 151.0, 147.2, 133.5, 131.3, 130.7, 127.7, 127.5, 124.7, 120.4, 116.8; HRMS (ESI+): calcd for C11H8N3O m/z 198.0667 [M+H], found 198.0673.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-iodobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fresneau, Nathalie; Cailly, Thomas; Fabis, Fre?de?ric; Bouillon, Jean-Philippe; Tetrahedron; vol. 69; 26; (2013); p. 5393 – 5400;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com