Reference of 622-50-4,Some common heterocyclic compound, 622-50-4, name is N-(4-Iodophenyl)acetamide, molecular formula is C8H8INO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under a nitrogen atmosphere, copper hydroxide (20 mol%, 2.5 mg) and a magnetite were added to a previously baked 10 mL glass pressure tube. Then, N,N-dimethylformamide (0.5 mL), 4-iodoacetanilide (0.125 mmol, 1.0 equiv., 32.6 mg) and phenylsilane (3.0 equiv., 40.6 mg) were added. The pressure tube was sealed and the tube air was removed and charged with carbon dioxide (5.0 equiv., 15 mL) and ammonia gas (0.67 mmol, 5.0 equiv., 15 mL). After the addition, the glass pressure tube was placed in a metal module that had been preheated to 160C and stirred for 10 hours. After the reaction was completed, the reaction system was cooled to room temperature and the pressure was slowly released. Using dodecane as an internal standard, the yield of the gas chromatograph was 97%.
The synthetic route of 622-50-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute Suzhou Institute; Li Yuehui; Wang Hua; Dong Yanan; Ke Lisitian¡¤shanduofu; (20 pag.)CN108017557; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com