Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 401-81-0
6b (458 mg, 2.00 mmol) in 1.0 ml of dry THF was initially introduced into a dry 10 ml microwave tube filled with argon and with a magnetic stirrer core and septum, and Zn(TMP)2.2LiCl.2MgCl2 in THF (3.2 ml, 0.37 M, 0.60 equivalent) was added at 25 C. The microwave tube was closed and the reaction was started. After 2 h in the microwave oven (120 W, 80 C.) the metallization was complete (GC analysis of reaction samples to which a solution of I2 in THF had been added indicated a conversion of more than 98%). After the reaction mixture had been cooled to room temperature, this was added to a solution of 3-CF3-C6H4-I (680 mg, 1.2 equivalents), Pd(dba)2 (5 mol %) and Tfp (10 mol %) in dry THF (2.5 ml). After stirring at 25 C. for 15 h, the reaction was ended by addition of saturated NH4Cl solution (30 ml). The aqueous phase was extracted with ethyl acetate (5¡Á30 ml), dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by filter column chromatography (silica gel; Et2O/pentane 1:15); 7b (680 mg, 76%) was obtained as a yellow oil.
According to the analysis of related databases, 401-81-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ludwig Maximilians Universitat Munchen; US2010/160632; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com