A common heterocyclic compound, 76801-93-9, name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 76801-93-9.
5-amino-N,N’-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (500 g) was taken in N-methylpyrrolidone (500 ml). Chloroacetyl chloride (500 ml) was then added over three hours maintaining the temperature below 35 0C. After addition, the reaction mixture was stirred for three hours at 50 0C. Water (1.3 L) was added to the reaction mass and the precipitated product was filtered, washed and dried. Yield: 97%Purity: 96% (by HPLC)
The synthetic route of 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; WOCKHARDT RESEARCH CENTRE; KULKARNI, Dilip, Ganesh; SINHA, Rohit, Kumar; SHINDE, Prakash, Sakharam; SIDDIQUI, Mohammed, Jaweed, Mukarram; ZAKIR, Gafoor, Shaikh; MOHAMMED, Ismail, Shafi; ANIS, Mushtaqe, Ali, Saiyad; KHAN, Nasim; WO2008/104853; (2008); A1;,
Iodide – Wikipedia,
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