608-28-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 608-28-6 name is 2-Iodo-1,3-dimethylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: A 10-mL glass vessel equipped with J. Young O-ring tap containing a magnetic stirring bar was flame-dried under vacuum and filled with argon after cooling to room temperature. To this tube were added 2-substituted 2H-indazole (1: 0.40 mmol), CuI (7.6 mg, 0.04 mmol), 1,10-phenanthroline (7.2 mg, 0.04 mmol), LiOt-Bu (64 mg, 0.80 mmol), and haloarene (2: 0.80 mmol), followed by DMF (0.5 mL) under a stream of argon. The tube was sealed with O-ring tap, and then heated at 110 C for 15 h in an eight-well reaction block with stirring. After cooling the reaction mixture to room temperature, the mixture was passed through a short pad of Celite (EtOAc). The filtrate was concentrated and the residue was subjected to preparative HPLC (acetonitrile/water as an eluent) to afford the arylated product 3.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Conference Paper; Hattori, Keika; Yamaguchi, Kazuya; Yamaguchi, Junichiro; Itami, Kenichiro; Tetrahedron; vol. 68; 37; (2012); p. 7605 – 7612;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com