124700-41-0, The chemical industry reduces the impact on the environment during synthesis 124700-41-0, name is 2-Fluoro-5-iodobenzoic acid, I believe this compound will play a more active role in future production and life.
Add bis (triphenylphosphine) palladium (II) dichloride (70 mg, 0. 10 mmol), copper (I) iodide (38 mg, 0. 20 mmol), and 3-ethynyl-5-methoxypyridine, (prepared as described in PREPARATION 10), (400 mg, 3. 0 mmol) to a solution of 2-fluoro-5-iodobenzoic acid (0. 53 g, 2. 0 mmol) in triethylamine (4. 2 mL, 30. 0 mmol) and stir at room temperature for 1 h. Heat at 50 C for 18 h. Cool to room temperature and concentrate. Purify by silica gel chromatography, eluting with 100 : 0 to 60 : 40 ethyl acetate : methanol. Triturate the resulting solid with 3 : 1 hexanes : methanol to give the title compound as an off-white solid (295 mg, 54%). 1H NMR (300 MHz, DMSO-d6) 6 3. 86 (s, 3H), 7. 09-7. 17 (m, 1H), 7. 46-7. 53 (m, 1H), 7. 55-7. 59 (m, 1H), 7. 81-7. 87 (m, 1H), 8. 24-8. 35 (m, 2H) ; MS (APCI) : m/z = 272 [M+H] +.
The chemical industry reduces the impact on the environment during synthesis 2-Fluoro-5-iodobenzoic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com