76801-93-9, Name is 5-Amino-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide, molecular formula is C14H18I3N3O6, belongs to iodides-buliding-blocks compound, is a common compound. In a patnet, author is Li, Huika, once mentioned the new application about 76801-93-9, Category: iodides-buliding-blocks.
Effect of iodide on human choriogonadotropin, sodium-iodide symporter expression, and iodide uptake in BeWo choriocarcinoma cells
Context: Active placental transport of maternal iodide by the thyroidal sodium iodide symporter ( NIS) provides an essential substrate for fetal thyroid hormone synthesis. NIS is expressed in trophoblast and is regulated by human choriogonadotropin ( hCG). In thyroid, iodide down- regulates expression of several genes including NIS. Placentas of iodine- deficient rats demonstrate up- regulation of NIS mRNA, suggesting a role for iodide in regulating placental NIS. Objectives and Methods: The objectives were to examine effects of iodide on expression of NIS and hCG in BeWo choriocarcinoma cells. Gene expression was studied by quantitative real- time PCR. Effects on NIS protein expression were assessed by Western blotting. Functional activity of NIS was measured by I-125 uptake. Expression of hCG protein was assessed by immunoassay of secreted hormone. Results: Iodide inhibited NIS mRNA and membrane protein expression as well as I-125 uptake, which were paralleled by decreased beta hCG mRNA expression and protein secretion. Iodide had no effects on pendrin expression. Addition of hCG increased NIS mRNA expression. This effect was partially inhibited by addition of iodide. The inhibitory effects of iodide on NIS mRNA expression were abolished by propylthiouracil and dithiothreitol. Conclusions: We conclude that expression of placental NIS is modulated by maternal iodide. This may occur through modulation of hCG effects on NIS and hCG gene expression.
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