Related Products of 135050-44-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 135050-44-1 name is 3-Chloro-4-iodoaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3-chloro-4-iodoaniline (15 g, 59 mmol) dissolved in diethyl [(ethyloxy)methylene]malonate (19 mL, 95 mmol) and heated at 160 C for 4 hours under a reflux condenser. The condenser was then removed and EtOH evaporated. After one hour, it was cooled to rt to solidify, broken up and the solid was suspended in hexane. The mixture was filtered and the filter cake washed with hexane several times to give a grey solid (23 g, 91%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloro-4-iodoaniline, and friends who are interested can also refer to it.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BURY, MICHAEL JONATHAN; CASILLAS, LINDA N.; CHARNLEY, ADAM KENNETH; HAILE, PAMELA A.; MARQUIS JR., ROBERT W.; MEHLMANN, JOHN F.; ROMANO, JOSEPH J.; SINGHAUS, JR., ROBERT R.; WANG, GREN Z.; (153 pag.)TWI609011; (2017); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com