Related Products of 42861-71-2, These common heterocyclic compound, 42861-71-2, name is 3-Iodophenyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirring solution of 3-iodo phenyl acetate (32.20 g, 123 mmol) in chlorobenzene (250 ml) under nitrogen was added aluminium chloride (31.00 g, 232 mmol, 1.9 equ). The reaction mixture was heated to [140C] for 90 hours then allowed to cool. The reaction mixture was poured onto ice/water and then filtered, and the residue washed with dichloromethane. The filtrate was then extracted with dichloromethane and the combined organic layers extracted with 10 [%] potassium hydroxide solution (3x 100 ml). The combined aqueous layers were then acidified with 6N hydrochloric acid and extracted with dichloromethane (3x 75 ml). This organic layer was then dried (MgSO4) and concentrated in vacuo to give 29 (22.3 g, 69 %) as a brown solid. [1H] nmr (400 MHz, [CDC13).] 2.60 (s, 3H) 7.26-7. 28 (m, [2H)] 7.42 (s, 1H) [12.] 26 [(S,] [1H). 13C] nmr (100 MHz, CDCl3) 26.596 [(CH3),] 103.768 (Q), [118. 997] (Q), 127. 833 (CH), 128.325 (CH), 131.251 (CH), 162.191 (Q), 204.214 (Q). CI+ 263.0 [(98] %, M+H+) 262 [(100%,] [M+). ACC. MASS.] (M+H) [CUSDH8O2I,] calc. 262.9569, found 262.9568. ir (GG) 2360g 1699g 1558g 1205. mp. 51.5- [52C] (lit. [52-54C*).]
The synthetic route of 42861-71-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ROWETT RESEARCH INSTITUTE; WO2004/7475; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com