Related Products of 628-21-7,Some common heterocyclic compound, 628-21-7, name is 1,4-Diiodobutane, molecular formula is C4H8I2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 50 mL flask compound 6 (100 mg, 0.43 mmol) and dry K2CO3 (80 mg, 0.50 mmol) were added to anhydrous DMF (3 mL). When the product was completelydissolved, an excess of 1,4-diiodobutane (0.5 mL) was added at room temperature. To the crude product distilled water (10 mL) was added and the solution was extracted three times with diethyl ether (30 mL). Then, the organic phase was washed three times with saturated aqueous NaCl solution(10 mL) and finally dried over Na2SO4. The product was purified by column chromatography(30%-60% CHCl3 in hexane), to give compound 7 was obtained as a white solid (237 mg, 0.39 mmol,91%).
The synthetic route of 628-21-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Altieri, Alessandro; Alvino, Antonello; Ohnmacht, Stephan; Ortaggi, Giancarlo; Neidle, Stephen; Nocioni, Daniele; Franceschin, Marco; Bianco, Armandodoriano; Molecules; vol. 18; 11; (2013); p. 13446 – 13470;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com