Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 188815-32-9, name is 3-Bromo-5-iodobenzoic acid, A new synthetic method of this compound is introduced below., SDS of cas: 188815-32-9
Example 50 Synthesis of 3-Bromo-5-hydroxy-benzoic acid; The title compound was made according to the method described in Org. Proc. Res. Dev. 2002, 6, 591-595. To 5- iodo-3-bromo-benzoic acid (500 mg, 1.53 mmol), NaOH (250 mg, 6.1 mmol), Cu20 (240 mg, 1.68 mmol) was added water (4.0 mL). The mixture was heated for 1.5 h at 140 C in a sealed tube. The cooled mixture was diluted with water and extracted with CH2Cl2. The aqueous layer was acidified (pH-2) with TFA and extracted with EtOAc. The organic layer was dried over Na2S04, filtered, concentrated and purified by reverse-phase HPLC to yield 3-bromo-5-hydroxy-benzoic acid. ?H NMR (400 MHz, DMSO-d6): 10.30 (s, 1H), 7.46 (m, 1H), 7.31 (m, 1H), 7.17 (m, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; AMGEN INC.; WO2005/113494; (2005); A2;,
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