Some common heterocyclic compound, 40400-15-5, name is 2-(2-Iodophenyl)acetonitrile, molecular formula is C8H6IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 2-(2-Iodophenyl)acetonitrile
A mixture of 4-((benzyloxy)methyl)-2H-1,2,3-triazole I58 (1.7 g, 9.0 mmol), 2-(2- iodophenyl)acetonitrile (3.0 g, 12.0 mmol), Fe(acac)3 (1.1 g, 3.0 mmol), CuO (720 mg, 0.9 mmol) and Cs2C03 (6.0 g, 18.0 mmol) in DMF (60 mL) was heated at 90 C under N2 for 30 h. The mixture was diluted with water and extracted with EtOAc. The combined organic extracts were washed with brine, dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to give the title compound (1.4 g, 51 %) as a yellow oil. LCMS-D: Rt 2.87 min; m/z 305.1 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 40400-15-5, its application will become more common.
Reference:
Patent; CTXT PTY LIMITED; MORROW, Benjamin Joseph; FOITZIK, Richard Charles; CAMERINO, Michelle Ang; LAGIAKOS, Helen Rachel; WALKER, Scott Raymond; BOZIKIS, Ylva Elisabet Bergman; STEVENSON, Graeme Irvine; CUZZUPE, Anthony Nicholas; STUPPLE, Paul Anthony; (313 pag.)WO2019/43139; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com