Related Products of 181765-86-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 181765-86-6, name is Methyl 5-bromo-2-iodobenzoate, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: An oven-dried Schlenk tube equipped with a Teflon valve was charged with a magnetic stir bar, CuI (10 mg, 0.05 mmol, 10 mol%), K2CO3 (276 mg, 2.0 mmol), 1,10-phenanthroline (20 mg, 0.10 mmol, 20 mol%) and cyclic thiourea (0.5 mmol), 4 ? Molecular Sieves. The tube was evacuated and backfilled with N2 (this procedure was repeated 3 times). Under a counter flow of N2, methyl-2-iodobenzoate 1 (0.6 mmol) and DMF (2.0 mL) were added by syringe. The mixture was stirred at 100 ?C for 24h. After the reaction was completed, the mixture was directly passed through celite and rinsed with 30 mL of EtOAc. The combined filtrate was concentrated and purified by column chromatography on silica gel to give the pure product.Yellow Yellow solid; mp 152-154 C; 1H NMR (200 MHz, CDCl3) delta 8.31 (d, J = 2.0 Hz, 1H), 7.56 (dd, J1 = 8.6 Hz, J2 = 2.4 Hz, 1H), 7.07 (d, J = 8.6 Hz, 1H), 3.53-3.39 (m, 1H), 3.29-3.15 (m, 1H), 3.07-3.02 (m, 1H), 2.38-2.33 (m, 1H), 1.90-1.86 (m, 2H), 1.74-1.34 (m, 4H); 13C NMR (50 MHz, CDCl3) delta 160.9, 153.8, 136.4, 133.3, 131.1, 126.8, 126.2, 120.6, 71.9, 67.6, 31.0, 30.7, 29.9, 25.4, 24.9 ppm. Anal. Calcd. for C14H13BrN2OS: C 49.86, H 3.89, N 8.31; found: C 50.05, H 4.01, N 8.20; EI-MS: m/z = 336 (M+), 338(M+2).
The chemical industry reduces the impact on the environment during synthesis Methyl 5-bromo-2-iodobenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Article; Chen, Dingben; Wu, Jiashou; Yang, Jianguo; Huang, Ling; Xiang, Yubo; Bao, Weiliang; Tetrahedron Letters; vol. 53; 52; (2012); p. 7104 – 7107;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com