Reference of 6293-83-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6293-83-0, name is 2-Iodo-4-nitroaniline belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
In a 20 mL dehydrated deoxygenated Schlenk tube, acetophenone p-toluenesulfonylhydrazone(0.30 mmol, 86.4 mg), 2-iodo-4-nitroaniline (0.2 mmol, 52.8 mg), bis triphenylphosphine palladium(0.02 mmol, 14.0 mg), sodium tert-butoxide (1.2 mmol, 115.2 mg) 3.0 mL diethylene glycol dimethyl ether (diglyme), and finally 0.1 MPa of CO2 was injected into the reaction tube. The sealed reaction tube was heated and stirred in an oil bath at 140 C for about 24 hours Rear. The reaction solution was acidified with 1.5 mL of a 1 M hydrochloric acid solution and extracted with ethyl acetate (4 mL x 5) The organic phases were combined and finally the product was purified by column chromatography and then dried to give 23.9 mg of a white solid powder as a solid45%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-4-nitroaniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Changzhou University; Sun, Song; Cheng, Jiang; Hu, Weiming; Gu, Ning; Wang, Bingbing; (12 pag.)CN106432074; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com