Synthetic Route of 624-76-0, The chemical industry reduces the impact on the environment during synthesis 624-76-0, name is 2-Iodoethanol, I believe this compound will play a more active role in future production and life.
Method B): R-lipoyl chloride (10.0g, 44.5mmol) and tetrahydrofuran (200mL) were added to the reaction flask, stirringN, N-dimethylaniline (16.2 g, 133.5 mmol) was added to the solution. The mixture was cooled in an ice bath and 2-iodoethanol (17.6 g, 102.3 mmol)The reaction mixture was reacted at 50 C for 3h. After treatment and purification, the crude product was recrystallized from a mixed solvent of ethyl acetate and n-hexane,R-lipoic acid was 2-iodoethyl ester, light yellow solid (14.1 g), yield 88%, the reaction formula is:
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodoethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Suzhou Fushilai Pharmaceutical Co., Ltd.; Mo Guoning; (9 pag.)CN107089967; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com